Mammalian genomes are pervasively transcribed, yielding a complex transcriptome with
high variability in composition and cellular abundance. Although recent efforts have identified …

… programmed rearrangements of T cell receptor-β (TCRβ) alleles during T cell maturation. …
If the first rearrangement produces a functional TCRβ allele, T cell maturation continues (left)…

… P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, as determined by an Unpaired t test
… P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001, as determined by an Unpaired t test …

An emerging theme in messenger RNA metabolism is the coupling of nuclear pre-mRNA
processing events, which contributes to mRNA quality control 1 . Most eukaryotic mRNAs …

… The sequences were obtained from the UniProt database and aligned using the T-coffee
server 59 . b Protein co-precipitations by pull down assays. GST-tagged MTR4∆N was …

Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly
found RNAs have functions and how many are byproducts of functional, or spurious, …

… not associated with dCP enhancer potential (t-test, P < 1 × 10 −16 ), while hkCP enhancer-associated
transcribed DHSs were associated with the highest expression levels (t-test, P < 1 …

Dynamic RNA-protein interactions govern the co-transcriptional packaging of RNA polymerase
II (RNAPII)-derived transcripts. Yet, our current understanding of this process in vivo …

ARS2 is a conserved protein centrally involved in both nuclear RNA productive and destructive
processes. To map features of ARS2 promoting RNA decay, we utilized two different …

… CD19+ B-cells and CD8+ T-cells were isolated using the pluriBead system (huCD4/CD8
cascade and huCD19 single; PluriSelect). RNA was then extracted using the miRNeasy kit (…