Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

The ϵ isoform of protein kinase C (PKCϵ) has emerged as a critical second messenger in
sensitization toward mechanical stimulation in models of neuropathic (diabetes, alcoholism, …

Background TRPV4 and the cellular cytoskeleton have each been reported to influence cellular
mechanosensitive processes as well as the development of mechanical hyperalgesia. If …

Nonsyndromic mental retardation is one of the most important unresolved problems in genetic
health care. Autosomal forms are far more common than X-linked forms, but, in contrast to …

Genomic instability can be a hallmark of both human genetic disease and cancer. We
identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome …

The genetic variants leading to impairment of intellectual performance are highly diverse
and are still poorly understood. ST3GAL3 encodes the Golgi enzyme β-galactoside-α2,3-…

Much work has focused on the electrophysiological properties of transient receptor potential
channels. Recently, a novel aspect of importance emerged: the interplay of transient …

The composition of tumor-infiltrating lymphocytes (TIL) reflects biology and immunogenicity
of cancer. Here, we characterize T-cell subsets and expression of immune checkpoint …

… We also included the core SG marker proteins T-cell-restricted intracellular antigen-1-related
protein (TIAR) and PABP in this analysis, and detected a co-localization of ATXN2L-…

The antimetabolite 5-fluorouracil is a widely used chemotherapeutic for the treatment of
several solid cancers. However, resistance to 5-fluorouracil remains a major drawback in its …