User profiles for T. Kroon

Tim Kroon

- Verified email at kcl.ac.uk - Cited by 664

Tobias Kroon, PhD

- Verified email at astrazeneca.com - Cited by 215

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

…, J Jezequel, D Exposito-Alonso, M Balia, T Kroon… - Science, 2019 - science.org
How neuronal connections are established and organized into functional networks
determines brain function. In the mammalian cerebral cortex, different classes of GABAergic …

The integrated modeling system STONE for calculating nutrient emissions from agriculture in the Netherlands

J Wolf, AHW Beusen, P Groenendijk, T Kroon… - … Modelling & Software, 2003 - Elsevier
For the Netherlands, a nutrient emission modeling system, called STONE, has been
developed. It was designed for evaluation at the national and regional scale of the effects of …

Effects of rising atmospheric CO2 on evapotranspiration and soil moisture: A practical approach for the Netherlands

B Kruijt, JPM Witte, CMJ Jacobs, T Kroon - Journal of Hydrology, 2008 - Elsevier
… We will quantify S gs , S T and F T in the successive sub-sections. First, we will use a
literature review of experimentally observed plant response to elevated CO 2 . This will give us …

[HTML][HTML] An operational, multi-scale, multi-model system for consensus-based, integrated water management and policy analysis: The Netherlands Hydrological …

…, JR Delsman, JC Hunink, HTL Massop, T Kroon - … Modelling & Software, 2014 - Elsevier
Water management in the Netherlands applies to a dense network of surface waters for
discharge, storage and distribution, serving highly valuable land-use. National and regional …

[HTML][HTML] Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex

T Kroon, E van Hugte, L van Linge, HD Mansvelder… - Scientific reports, 2019 - nature.com
Mammalian neocortex is a highly layered structure. Each layer is populated by distinct
subtypes of principal cells that are born at different times during development. While the …

[HTML][HTML] The SGLT2 inhibitor dapagliflozin promotes systemic FFA mobilization, enhances hepatic β-oxidation, and induces ketosis

K Wallenius, T Kroon, T Hagstedt, L Löfgren… - Journal of lipid …, 2022 - ASBMB
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to increase ketone
bodies in patients with type 2 diabetes; however, the underlying mechanisms have not been …

[HTML][HTML] Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

…, C Kortleven, AA Galakhova, AJ Khalil, T Kroon… - Nature …, 2019 - nature.com
Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of
vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are …

[HTML][HTML] Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex

…, A Kerkhofs, NA Goriounova, T Kroon… - Nature …, 2018 - nature.com
A variety of inhibitory pathways encompassing different interneuron types shape activity of
neocortical pyramidal neurons. While basket cells (BCs) mediate fast lateral inhibition …

[HTML][HTML] PPARγ and PPARα synergize to induce robust browning of white fat in vivo

T Kroon, M Harms, S Maurer, L Bonnet… - Molecular …, 2020 - Elsevier
Objective Peroxisome proliferator-activated receptors (PPARs) are key transcription factors
that regulate adipose development and function, and the conversion of white into brown-like …

Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats

T Kroon, T Hagstedt, I Alexandersson, A Ferm… - Science Translational …, 2022 - science.org
Kroon et al. now show that timing administration of a small-molecule GKA to feeding periods
resulted in improved glycemic control and attenuated hepatosteatosis and inflammation in …