Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
How neuronal connections are established and organized into functional networks
determines brain function. In the mammalian cerebral cortex, different classes of GABAergic …
determines brain function. In the mammalian cerebral cortex, different classes of GABAergic …
The integrated modeling system STONE for calculating nutrient emissions from agriculture in the Netherlands
J Wolf, AHW Beusen, P Groenendijk, T Kroon… - … Modelling & Software, 2003 - Elsevier
For the Netherlands, a nutrient emission modeling system, called STONE, has been
developed. It was designed for evaluation at the national and regional scale of the effects of …
developed. It was designed for evaluation at the national and regional scale of the effects of …
Effects of rising atmospheric CO2 on evapotranspiration and soil moisture: A practical approach for the Netherlands
B Kruijt, JPM Witte, CMJ Jacobs, T Kroon - Journal of Hydrology, 2008 - Elsevier
… We will quantify S gs , S T and F T in the successive sub-sections. First, we will use a
literature review of experimentally observed plant response to elevated CO 2 . This will give us …
literature review of experimentally observed plant response to elevated CO 2 . This will give us …
[HTML][HTML] An operational, multi-scale, multi-model system for consensus-based, integrated water management and policy analysis: The Netherlands Hydrological …
…, JR Delsman, JC Hunink, HTL Massop, T Kroon - … Modelling & Software, 2014 - Elsevier
Water management in the Netherlands applies to a dense network of surface waters for
discharge, storage and distribution, serving highly valuable land-use. National and regional …
discharge, storage and distribution, serving highly valuable land-use. National and regional …
[HTML][HTML] Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex
Mammalian neocortex is a highly layered structure. Each layer is populated by distinct
subtypes of principal cells that are born at different times during development. While the …
subtypes of principal cells that are born at different times during development. While the …
[HTML][HTML] The SGLT2 inhibitor dapagliflozin promotes systemic FFA mobilization, enhances hepatic β-oxidation, and induces ketosis
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been shown to increase ketone
bodies in patients with type 2 diabetes; however, the underlying mechanisms have not been …
bodies in patients with type 2 diabetes; however, the underlying mechanisms have not been …
[HTML][HTML] Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
…, C Kortleven, AA Galakhova, AJ Khalil, T Kroon… - Nature …, 2019 - nature.com
Neocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of
vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are …
vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are …
[HTML][HTML] Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
…, A Kerkhofs, NA Goriounova, T Kroon… - Nature …, 2018 - nature.com
A variety of inhibitory pathways encompassing different interneuron types shape activity of
neocortical pyramidal neurons. While basket cells (BCs) mediate fast lateral inhibition …
neocortical pyramidal neurons. While basket cells (BCs) mediate fast lateral inhibition …
[HTML][HTML] PPARγ and PPARα synergize to induce robust browning of white fat in vivo
Objective Peroxisome proliferator-activated receptors (PPARs) are key transcription factors
that regulate adipose development and function, and the conversion of white into brown-like …
that regulate adipose development and function, and the conversion of white into brown-like …
Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats
T Kroon, T Hagstedt, I Alexandersson, A Ferm… - Science Translational …, 2022 - science.org
… Kroon et al. now show that timing administration of a small-molecule GKA to feeding periods
resulted in improved glycemic control and attenuated hepatosteatosis and inflammation in …
resulted in improved glycemic control and attenuated hepatosteatosis and inflammation in …