The mammalian circadian timing system is composed of a central pacemaker in the
suprachiasmatic nucleus (SCN) of the brain and subsidiary oscillators in most peripheral cell types. …

Based on results recorded of perioperative mortality, anaesthetic care is often cited as a model
for its improvements with regard to patient safety. However, anaesthesia-related morbidity …

The silent mating loci and chromosomal regions adjacent to telomeres of S. cerevisiae have
features similar to heterochromatin of more complex eukaryotes. Transcriptional repression …

The management of hepatocellular carcinoma (HCC) remains challenging due to late
presentation and the presence of accompanying liver dysfunction. As such, most patients are not …

… PCR products were directly cloned into pGEM-T (Promega) and a partial 157-bp cDNA
was … & de Lange, T. A mammaliari factor that binds telomeric TTAGGG repeats in vitro. Mol. …

Heritable inactivation of genes occurs in specific chromosomal domains located at the silent
mating type loci and at telomeres of S. cerevisiae. The SIR genes (for silent information …

Telomeric TG-rich repeats and their associated proteins protect the termini of eukaryotic
chromosomes from end-to-end fusions. Associated with the cap structure at yeast telomeres is a …

We have developed a novel technique for combined immunofluorescence/in situ hybridization
on fixed budding yeast cells that maintains the three-dimensional structure of the nucleus …

Little is known about the dynamics of chromosomes in interphase nuclei. By tagging four
chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored the …

SC1 is a prominent, 170,000 M r , non-histone protein of HeLa metaphase chromosomes.
This protein binds DNA and was previously identified as one of the major structural …