Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify
candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although …

… pathways implicated in muscle hypertrophy on the basis of findings in vitro 3 , 4 , 5 , 6 , Akt/mTOR
(mammalian target of rapamycin) and calcineurin/NFAT (nuclear factor of activated T …

Skeletal muscle size depends upon a dynamic balance between anabolic (or hypertrophic)
and catabolic (or atrophic) processes. Previously, no link between the molecular mediators …

… However, the signalling pathways by which IGF-1 promotes hypertrophy remain unclear,
with roles suggested for both the calcineurin/NFAT (nuclear factor of activated T cells) pathway …

A variety of findings seem to functionally link brainderived neurotrophic factor (BDNF))’and
neurotrophin3 (NT-3), while distinguishing both of these factors from the third member of the …

We report the identification of Iigands for Tyro 3 (alternatively called Sky, rse, brt, or tit) and
Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine …

Formation of the neuromuscular junction depends upon reciprocal inductive interactions
between the developing nerve and muscle, resulting in the precise juxtaposition of a …

Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids
such as dexamethasone (DEX) and is a hallmark of cachectic syndromes associated with …

Skeletal muscle atrophy is a severe morbidity caused by a variety of conditions, including
cachexia, cancer, AIDS, prolonged bedrest, and diabetes. One strategy in the treatment of …

We have exploited a battery of approaches to address several controversies that have
accompanied the expansion of the nerve growth factor (NCF) family of neurotrophic factors and …