Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age
with a peak incidence in adolescents and young adults. The treatment of ES relies on a …

Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes and …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some entities …

… Administrative support: Uta Dirksen … Marie Cécile Le Deley, Odile Oberlin, Alan Craft
Manuscript writing: Ruth Ladenstein, Ulrike Pötschger, Marie Cécile Le Deley, Jeremy …

Background The prognosis in patients with relapsed Ewing sarcoma is unfavorable. Our
investigation identifies factors predicting for the outcome following relapse. Procedure We …

The ‘Individualized Therapy for Relapsed Malignancies in Childhood’ (INFORM) precision
medicine study is a nationwide German program for children with high-risk relapsed/refractory …

Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

X-linked severe combined immunodeficiency is a recessive hereditary disease characterized
by severe and persistent infections starting in the first months of life and associated with …