Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the
precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence …

During the past decades, anticancer immunotherapy has evolved from a promising therapeutic
option to a robust clinical reality. Many immunotherapeutic regimens are now approved …

To optimize vaccination strategies, it is important to use protocols that can 'jump-start' immune
responses by harnessing cells of the innate immune system to assist the expansion of …

The viruses HIV-1, Epstein–Barr virus (EBV), cytomegalovirus (CMV) and hepatitis C virus (HCV)
are characterized by the establishment of lifelong infection in the human host, where …

10.7554/eLife.01202.001 Rheumatoid arthritis (RA) is a prevalent systemic autoimmune
disease, caused by a combination of genetic and environmental factors. Animal models suggest …

Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human
immunodeficiency virus–type 1 (HIV-1) infection, it has not been possible to demonstrate a …

Extracts of bovine hypothalamus were found to contain a significant level of mitogenic activity
when tested in a Swiss 3T3 cell [3H]dThd incorporation assay and in a human umbilical …

The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function
and represents a specific marker for these cells. Despite its strong association with regulatory …

The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits
natural killer (NK) cell–mediated lysis by interacting with CD94/NKG2A receptors. Surface …

In mouse, a subset of dendritic cells (DCs) known as CD8α + DCs has emerged as an
important player in the regulation of T cell responses and a promising target in vaccination …