The acetylation of histones increases the accessibility of nucleosomal DNA to transcription
factors [1,2], relieving transcriptional repression [3] and correlating with the potential for …

p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific
activators via direct interactions. Various cellular and viral factors target p300/CBP to …

The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to
the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-…

It is well known that histone acetylases are important chromatin modifiers and that they play
a central role in chromatin transcription. Here, we present evidence for novel roles of histone …

Modification of histones, DNA-binding proteins found in chromatin, by addition of acetyl groups
occurs to a greater degree when the histones are associated with transcriptionally active …

The products of the p53 and CBP/p300 genes have been individually implicated in control
of cell growth and regulation of transcription. p53 is known to act as a positive and negative …

PCAF histone acetylase plays a role in regulation of transcription, cell cycle progression, and
differentiation. Here, we show that PCAF is found in a complex consisting of more than 20 …

The androgen receptor (AR) is a sequence-specific DNA-binding protein that plays a key
role in prostate cancer cellular proliferation by dihydrotestosterone and the induction of …

Histone acetyltransferases (HAT) play a critical role in transcriptional control by relieving
repressive effects of chromatin, and yet how HATs themselves are regulated remains largely …

PCAF is a histone acetyltransferase that associates with p300/CBP and competes with E1A
for access to them. While exogenous expression of PCAF potentiates both MyoD-directed …