Background Long-term prognosis for localized pancreatic cancer remains poor. We sought to
assess the benefit of neoadjuvant/preoperative chemotherapy with or without radiotherapy. …

CZE and CIEF of proteins have preceded, and accompanied, the birth of proteomics. Although
they might not be fully exploited in massive proteomic analyses (especially those projects …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Importance In December 2019, a novel coronavirus (severe acute respiratory syndrome
coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. …

Importance Many patients with coronavirus disease 2019 (COVID-19) are critically ill and
require care in the intensive care unit (ICU). Objective To evaluate the independent risk factors …

Somatic cell nuclear transfer, cell fusion, or expression of lineage-specific factors have been
shown to induce cell-fate changes in diverse somatic cell types 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , …

The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse
and human fibroblasts. We previously described direct reprogramming of adult mouse neural …

Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining
pluripotency and further opens up the possibility of generating patient-specific pluripotent …

The combination of induced pluripotent stem cell (iPSC) technology and targeted gene
modification by homologous recombination (HR) represents a promising new approach to …

Phelan–McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized
by global developmental delay, severely impaired speech, intellectual disability, and an …