Publisher Summary This chapter reviews that collagen constitutes the major protein component
of skin, bone, tendon, and all the other forms of connective tissue. An understanding of …

… Addition of KCI to a solution of these minifilaments (at pH 8.0) results in rapid bilateral growth
(231) to form the 0.63-llm-Iong synthetic filaments described by Josephs & Harrington (213)…

Most human epithelial tumors harbor numerous alterations, making it difficult to predict which
genes are required for tumor survival. To systematically identify cancer dependencies, we …

The CRISPR–Cas9 system has revolutionized gene editing both at single genes and in
multiplexed loss-of-function screens, thus enabling precise genome-scale identification of genes …

The development of clinically viable delivery methods presents one of the greatest challenges
in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report …

The CRISPR/Cas9 system enables genome editing and somatic cell genetic screens in
mammalian cells. We performed genome-scale loss-of-function screens in 33 cancer cell lines to …

… A low molecular weight polymer (B2, see Harrington and Sela11) gave an … If it is assumed
that polyproline I has a right handed helical structure suggested by Harrington and Sela,11 …

… Earlier studies (Harrington and von Hippel, 1961; Josse and Harrington, 1964) have
called attention to the apparent dependence of renaturation rate of gelatin chains, compared …

Pharmacologically difficult targets, such as MYC transcription factors, represent a major
challenge in cancer therapy. For the childhood cancer neuroblastoma, amplification of the …

Genetic and chemical perturbations impact diverse cellular phenotypes, including multiple
indicators of cell health. These readouts reveal toxicity and antitumorigenic effects relevant to …