… : W. Ruebberdt is employed by Wyeth Pharmaceuticals, Germany. WG Rossmanith reports
no … Freedman RR, Krell W. Reduced thermoregulatory null zone in postmenopausal women …

Mitochondrial tRNAs are generally synthesized as part of polycistronic transcripts. Release
of tRNAs from these precursors is thus not only required to produce functional adaptors for …

tRNAs are synthesized as immature precursors, and on their way to functional maturity, extra
nucleotides at their 5′ ends are removed by an endonuclease called RNase P. All RNase …

Seventy-eight bovine viral diarrhoea viruses (BVDV) recently collected in Austria, France,
Hungary, Italy, Slovakia, Spain and UK were genetically typed in the 5′-untranslated (5′UTR…

Modifications on mRNA offer the potential of regulating mRNA fate post-transcriptionally.
Recent studies suggested the widespread presence of N 1 -methyladenosine (m 1 A), which …

N6-methyladenosine (m6A), a widespread destabilizing mark on mRNA, is non-uniformly
distributed across the transcriptome, yet the basis for its selective deposition is unknown. Here, …

N6-methyladenosine (m 6 A) is the most abundant modification on mRNA and is implicated
in critical roles in development, physiology, and disease. A major limitation has been the …

The ubiquitous endonuclease RNase P is responsible for the 5′ maturation of tRNA
precursors. Until the discovery of human mitochondrial RNase P, these enzymes had typically …

Transfer RNAs (tRNAs) reach their mature functional form through several steps of processing
and modification. Some nucleotide modifications affect the proper folding of tRNAs, and …

tRNA processing is a central event in mammalian mitochondrial gene expression. We have
identified key enzymatic activities (ribonuclease P, precursor tRNA 3′-endonuclease, and …