Integrated sequencing strategies have provided a broader understanding of the genomic
landscape and molecular classifications of multiple cancer types and have identified various …

We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to
demonstrate the ability to accurately and robustly determine whether individuals are in a complex …

Background Family history is a significant risk factor for prostate cancer, although the
molecular basis for this association is poorly understood. Linkage studies have implicated …

The longitudinal evolution of a myeloma genome from diagnosis to plasma cell leukemia
has not previously been reported. We used whole-genome sequencing (WGS) on 4 purified …

Contemporary biological technologies produce extremely high-dimensional data sets from
which to design classifiers, with 20,000 or more potential features being common place. In …

The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue- such as the inability to biopsy or …

Age-related hearing impairment (ARHI), or presbycusis, is the most prevalent sensory
impairment in the elderly. ARHI is a complex disease caused by an interaction between …

There has been a growing interest in using next-generation sequencing (NGS) to profile
extracellular small RNAs from the blood and cerebrospinal fluid (CSF) of patients with …

Advanced prostate cancer can progress to systemic metastatic tumors, which are generally
androgen insensitive and ultimately lethal. Here, we report a comprehensive genomic survey …

The brain is a common site of metastatic disease in patients with breast cancer, which has
few therapeutic options and dismal outcomes. The purpose of our study was to identify …