User profiles for X. C. Dopico

Xaquin Castro Dopico

Karolinska Institutet
Verified email at ki.se
Cited by 1609

Drivers of infectious disease seasonality: potential implications for COVID-19

…, ES Schernhammer, XC Dopico… - Journal of biological …, 2021 - journals.sagepub.com
Not 1 year has passed since the emergence of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). Since its …

[HTML][HTML] Widespread seasonal gene expression reveals annual differences in human immunity and physiology

XC Dopico, M Evangelou, RC Ferreira, H Guo… - Nature …, 2015 - nature.com
Seasonal variations are rarely considered a contributing component to human tissue function
or health, although many diseases and physiological process display annual periodicities. …

Neutralisation sensitivity of the SARS-CoV-2 omicron (B. 1.1. 529) variant: a cross-sectional study

…, C Kim, RA Ehling, A Pankow, XC Dopico… - The Lancet Infectious …, 2022 - thelancet.com
Background The SARS-CoV-2 omicron (B.1.1.529) variant, which was first identified in
November, 2021, spread rapidly in many countries, with a spike protein highly diverged from …

[HTML][HTML] IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

…, HZ Simons, WS Thompson, AJ Cutler, XC Dopico… - Diabetologia, 2015 - Springer
Aims/hypothesis Type 1 diabetes results from the autoimmune destruction of insulin-secreting
pancreatic beta cells by T cells. Despite the established role of T cells in the pathogenesis …

[PDF][PDF] Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

…, A Nicoletto, DJ Sheward, H Das, XC Dopico… - Immunity, 2023 - cell.com
The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …

Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria

…, V Kyriakidis, J Zhang, XC Dopico… - Nucleic acids …, 2023 - academic.oup.com
The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet many
molecular details of mitochondrial translation remain elusive. It has been commonly held …

[PDF][PDF] Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles

NV Bernat, M Corcoran, I Nowak, M Kaduk, XC Dopico… - Immunity, 2021 - cell.com
Definition of the specific germline immunoglobulin (Ig) alleles present in an individual is a
critical first step to delineate the ontogeny and evolution of antigen-specific antibody responses…

[PDF][PDF] SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses

…, C Kim, M Ądori, K Lenart, K Loré, XC Dopico… - Cell Reports …, 2021 - cell.com
The outbreak and spread of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2)
is a current global health emergency, and effective prophylactic vaccines are needed …

[HTML][HTML] Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

…, X Yang, AJ Cutler, J Oliveira, XC Dopico… - Journal of …, 2017 - Elsevier
Identification of alterations in the cellular composition of the human immune system is key to
understanding the autoimmune process. Recently, a subset of FOXP3 + cells with low CD25 …

[HTML][HTML] Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2

…, M Mashar, J Brady, N Savinykh, XC Dopico… - JCI insight, 2017 - ncbi.nlm.nih.gov
The maintenance of peripheral naive T lymphocytes in humans is dependent on their
homeostatic division, not continuing emigration from the thymus, which undergoes involution with …