The availability of the human and mouse genome sequences has allowed the identification
and comparison of their respective degradomes — the complete repertoire of proteases that …

Purpose: Germ-line mutations in the exonuclease domains of POLE and POLD1 have been
recently associated with polyposis and colorectal cancer (CRC) predisposition. Here, we …

… genes implicated in immunological functions (XS Puente, A. Gutiérrez-Fernández, LaD.W. …
chimpanzee, including caspase 12 and napsin B (XS Puente, A. Gutiérrez-Fernández, LaD.W. …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western
countries, is a heterogeneous disease with variable clinical presentation and evolution 1 , 2 . …

Here we perform whole-exome sequencing of samples from 105 individuals with chronic
lymphocytic leukemia (CLL) 1 , 2 , the most frequent leukemia in adults in Western countries. …

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …

The zebra finch is an important model organism in several fields 1 , 2 with unique relevance
to human neuroscience 3 , 4 . Like other songbirds, the zebra finch communicates through …

Integrin-mediated adhesion promotes cell survival in vitro, whereas integrin antagonists
induce apoptosis of adherent cells in vivo. Here, we demonstrate that cells adherent within a …

‘Orang-utan’ is derived from a Malay term meaning ‘man of the forest’ and aptly describes the
southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo …