The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research
and clinical practice. Scientific advances in the past 7 years suggest that they might no …

… Thus, confirmed accumulation of disability would be defined by a worsening of EDSS that
persists over x months, agnostic to functional system, as has frequently been used. A more …

In patients presenting with a clinically isolated syndrome, MRI can support and substitute
clinical information in the diagnosis of multiple sclerosis by showing disease dissemination in …

… This consensus-based recommendation is justified by comparing diagnostic criteria for
PPMS36 and by a subsequent reanalysis of these data (X. Montalban, personal communication). …

Background Fingolimod (FTY720), a sphingosine-1-phosphate–receptor modulator that
prevents lymphocyte egress from lymph nodes, showed clinical efficacy and improvement on …

Background An evolving understanding of the immunopathogenesis of multiple sclerosis
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …

Background B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized
monoclonal antibody that selectively depletes CD20+ B cells. Methods In two identical …

Background: There is no consensus method for determining progression of disability in patients
with multiple sclerosis (MS) when each patient has had only a single assessment in the …

… X Montalban has received honoraria/consulting fees from Biogen Idec, Wyeth, Novartis,
and Bristol Myers Squibb; lecture fees from Biogen Idec, Serono and Schering; and grant …

Background and objectives Diagnosis of multiple sclerosis (MS) requires exclusion of diseases
that could better explain the clinical and paraclinical findings. A systematic process for …