[HTML][HTML] Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment

XS Chen, RH Reader, A Hoischen, JA Veltman… - Scientific reports, 2017 - nature.com
A significant proportion of children have unexplained problems acquiring proficient linguistic
skills despite adequate intelligence and opportunity. Developmental language disorders …

The epigenetics of non-coding RNA

LJ Collins, B Schönfeld, XS Chen - Handbook of epigenetics, 2011 - Elsevier
Publisher Summary This chapter reviews both the long and short classes of noncoding RNA
involved in epigenetic regulation—those that generally act as cis-acting silencers, but also …

[HTML][HTML] Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders

P Devanna, XS Chen, J Ho, D Gajewski, SD Smith… - Molecular …, 2018 - nature.com
Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric
disorders is a major challenge given their prevalence and potential severity for quality of life. …

Ancestral RNA: the RNA biology of the eukaryotic ancestor

LJ Collins, XS Chen - RNA biology, 2009 - Taylor & Francis
Our knowledge of RNA biology within eukaryotes has exploded over the last five years. Within
new research we see that some features that were once thought to be part of multicellular …

[HTML][HTML] Computational Identification of Four Spliceosomal snRNAs from the Deep-Branching Eukaryote Giardia intestinalis

XS Chen, WTJ White, LJ Collins, D Penny - PLoS One, 2008 - journals.plos.org
RNAs processing other RNAs is very general in eukaryotes, but is not clear to what extent it
is ancestral to eukaryotes. Here we focus on pre-mRNA splicing, one of the most important …

[HTML][HTML] A novel approach identifies the first transcriptome networks in bats: a new genetic model for vocal communication

P Rodenas-Cuadrado, XS Chen, L Wiegrebe, U Firzlaff… - bmc Genomics, 2015 - Springer
Background Bats are able to employ an astonishingly complex vocal repertoire for navigating
their environment and conveying social information. A handful of species also show …

Computational identification of new structured cis -regulatory elements in the 3′-untranslated region of human protein coding genes

XS Chen, CM Brown - Nucleic acids research, 2012 - academic.oup.com
Messenger ribonucleic acids (RNAs) contain a large number of cis -regulatory RNA
elements that function in many types of post-transcriptional regulation. These cis -regulatory …

Finding functional disease-associated non-coding variation using next-generation sequencing

P Devanna, XS Chen, J Ho, D Gajewski, A Gialluisi… - bioRxiv, 2016 - biorxiv.org
Next generation sequencing has opened the way for the large scale interrogation of cohorts
at the whole exome, or whole genome level. Currently, the field largely focuses on potential …

A novel approach reveals first molecular networks in the bat brain: implications for vocal communication

SC Vernes, P Rodenas-Cuadrado, XS Chen… - the International …, 2015 - pure.mpg.de
Bats are able to employ an astonishin-gly complex vocal repertoire for navigating their
environment and conveying social information. A handful of species also show evidence for vocal …

[CITATION][C] Deciphering the 3'UTRome: identification and functional characterization of non-coding variants causing neurodevelopmental disorders

P Devanna, XS Chen, J Ho, D Gajewski… - the 7th EMBO …, 2016 - pure.mpg.de
Deciphering the 3'UTRome: identification and functional characterization of non-coding
variants causing neurodevelopmental disorders :: MPG.PuRe English Help Privacy Policy …