Cellular senescence, an irreversible growth arrest triggered by a variety of stressors, plays
important roles in normal physiology and tumor suppression, but accumulation of senescent …

Polycomb group (PcG) factors maintain facultative heterochromatin and mediate many
important developmental and differentiation processes. EZH2, a PcG histone H3 lysine-27 …

Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is
known to originate mainly from apoptotic cells. Here, we provide the first in vivo evidence of …

Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation
that can be transmitted to neighboring cells through secreted factors of the senescence-…

Objectives Clinical heterogeneity is a cardinal feature of systemic sclerosis (SSc). Hallmark
SSc autoantibodies are central to diagnosis and associate with distinct patterns of skin-…

Background Skin fibrosis is a hallmark feature of systemic sclerosis. Skin biopsy transcriptomics
and blister fluid proteomics give insight into the local environment of the skin. We have …

Compositional and transcriptional changes in the hematopoietic system have been used as
biomarkers of immunosenescence and aging. Here, we use single-cell RNA-sequencing to …

Sea urchin embryos are excellent for in vivo functional studies because of their transparency
and tractability in manipulation. They are also favorites for pharmacological approaches …

Background Glioblastoma (GBM) is an aggressive, age‐associated malignant glioma that
contains populations of cancer stem cells. These glioma stem cells (GSCs) evade therapeutic …

… Consistently with this model, we see that the subpopulations we observe show similar gene
expression patterns as described in the study conducted by Teo et al. [11] where a primary …