Background The benefits and safety of the treatment of mild chronic hypertension (blood
pressure, <160/100 mm Hg) during pregnancy are uncertain. Data are needed on whether a …

Background The perinatal and maternal consequences of induction of labor at 39 weeks
among low-risk nulliparous women are uncertain. Methods In this multicenter trial, we randomly …

The vast majority of prenatal genetic testing requires invasive sampling. However, this
poses a risk to the fetus, so one must make a decision that weighs the desire for genetic …

The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate
that these adaptations are precisely timed, reflecting an immune clock of pregnancy in …

OBJECTIVE: The purpose of this study was to describe the outcomes of a 10-year cohort of
pregnancies in patients with systemic lupus erythematosus and to evaluate clinical and …

Circulating cell-free RNA in the blood provides a potential window into the health,
phenotype, and developmental programs of a variety of human organs. We used high-throughput …

Background The metagenomic analysis of microbial communities holds the potential to
improve our understanding of the role of microbes in clinical conditions. Recent, dramatic …

Background Preterm birth is the leading cause of neonatal mortality and morbidity in
developed countries. Whether continued tocolysis after 48 hours of rescue tocolysis improves …

Background Primary cytomegalovirus (CMV) infection during pregnancy carries a risk of
congenital infection and possible severe sequelae. There is no established intervention for …

OBJECTIVE: The purpose of this study was to demonstrate that digital polymerase chain
reaction (PCR) enables rapid, allele independent molecular detection of fetal aneuploidy. …