What are the hallmarks of cancer?

Y Lazebnik - Nature Reviews Cancer, 2010 - nature.com
The seminal article by Douglas Hanahan and Robert Weinberg on the hallmarks of cancer is
10 years old this year and its contribution to how we see cancer has been substantial. But, in …

[PDF][PDF] Cell fusion: a hidden enemy?

D Duelli, Y Lazebnik - Cancer cell, 2003 - cell.com
… Our own experiments indicated that fusion of drug-sensitive transformed cells to primary
cells results in heterokaryons that are resistant to apoptosis (Duelli and Lazebnik, 2000). …

Cell-to-cell fusion as a link between viruses and cancer

D Duelli, Y Lazebnik - Nature Reviews Cancer, 2007 - nature.com
The ability to fuse cells is shared by many viruses, including common human pathogens and
several endogenous viruses. Here we will discuss how cell fusion can link viruses to cancer…

Caspases: enemies within

NA Thornberry, Y Lazebnik - Science, 1998 - science.org
Y. Lazebnik is at Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY
Lazebnik is at Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY …

Caspases disrupt the nuclear-cytoplasmic barrier

L Faleiro, Y Lazebnik - The Journal of cell biology, 2000 - rupress.org
… We are indebted to Ludwig Englmeier for generously sharing his expertise in nuclear
transport, members of the Lazebnik lab and Mike Myers for suggestions, Ximena Opitz-Araya for …

[HTML][HTML] Can a biologist fix a radio?—Or, what I learned while studying apoptosis

Y Lazebnik - Cancer cell, 2002 - cell.com
As a freshly minted Assistant Professor, I feared that everything in my field would be discovered
before I even had a chance to set up my laboratory. Indeed, the field of apoptosis, which I …

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

…, Y Gareau, PR Griffin, M Labelle, YA Lazebnik… - Nature, 1995 - nature.com
The protease responsible for the cleavage of poly(ADP-ribose) polymerase and necessary
for apoptosis has been purified and characterized. This enzyme, named apopain, is …

Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE

YA Lazebnik, SH Kaufmann, S Desnoyers, GG Poirier… - Nature, 1994 - nature.com
RECENT studies suggest that pro teases of the inter leukin 1-β-con-verting enzyme (ICE)/ced-3
family are involved in initiating the active phase of apoptosis 1–3 . Here we identify a …

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

…, R McCombie, JG Herman, WL Gerald, YA Lazebnik… - Nature, 2001 - nature.com
Metastatic melanoma is a deadly cancer that fails to respond to conventional chemotherapy
and is poorly understood at the molecular level 1 . p53 mutations often occur in aggressive …

[HTML][HTML] Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

…, R Mukattash, L Cilenti, G DuBois, Y Lazebnik… - Journal of Biological …, 2002 - ASBMB
To identify human proteins that bind to the Smac and caspase-9 binding pocket on the
baculoviral inhibitor of apoptosis protein (IAP) repeat 3 (BIR3) domain of human XIAP, we used …