User profiles for Y. Loe-Mie

Yann Loe-Mie

Institut Pasteur
Verified email at pasteur.fr
Cited by 2151

Two independent modes of chromatin organization revealed by cohesin removal

…, A Pekowska, G Fudenberg, Y Loe-Mie… - Nature, 2017 - nature.com
Imaging and chromosome conformation capture studies have revealed several layers of
chromosome organization, including segregation into megabase-sized active and inactive …

[PDF][PDF] Cnidarian cell type diversity and regulation revealed by whole-organism single-cell RNA-Seq

…, F Plessier, MP Mailhé, J Renno, Y Loe-Mie… - Cell, 2018 - cell.com
The emergence and diversification of cell types is a leading factor in animal evolution. So far,
systematic characterization of the gene regulatory programs associated with cell type …

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity

M Boulch, M Cazaux, Y Loe-Mie, R Thibaut… - Science …, 2021 - science.org
Chimeric antigen receptor (CAR) T cell therapy relies on the activity of a large pool of tumor-targeting
cytotoxic effectors. Whether CAR T cells act autonomously or require interactions …

Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors

S Haziza, N Mohan, Y Loe-Mie… - Nature …, 2017 - nature.com
… Using the Track Manager plugin, we exported a text file containing the spot (x,y) coordinates
and the signal amplitude and background (based on a 2D Gaussian fitting of fluorescence …

DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down …

…, N Ramoz, S Imbeaud, Y Loe-Mie… - Human molecular …, 2009 - academic.oup.com
The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome
(DS), the most frequent cause of mental retardation, have remained elusive. Here we use …

SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution

Y Loe-Mie, AM Lepagnol-Bestel… - Human molecular …, 2010 - academic.oup.com
The SMARCA2 gene, which encodes BRM in the SWI/SNF chromatin-remodeling complex,
was recently identified as being associated with schizophrenia (SZ) in a genome-wide …

Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism

…, AM Lepagnol-Bestel, F Tores, Y Loe-Mie… - Human molecular …, 2008 - academic.oup.com
Autism spectrum disorders (ASDs) are common, heritable, but genetically heterogeneous
neurodevelopmental conditions. We recently defined a susceptibility locus for ASDs on …

[HTML][HTML] HENA, heterogeneous network-based data set for Alzheimer's disease

…, T Moncion, V Collura, R Daudin, Y Loe-Mie, Y Herault… - Scientific data, 2019 - nature.com
Alzheimer’s disease and other types of dementia are the top cause for disabilities in later
life and various types of experiments have been performed to understand the underlying …

[PDF][PDF] Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures

JC Cossec, T Traboulsi, S Sart, Y Loe-Mie… - Cell Reports, 2023 - cell.com
Recent advances in synthetic embryology have opened new avenues for understanding the
complex events controlling mammalian peri-implantation development. Here, we show that …

[HTML][HTML] Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity

…, A Sebé-Pedrós, B Saudemont, Y Loe-Mie… - Nature …, 2024 - nature.com
Phylogenetic analyses over the last two decades have united a few small, and previously
orphan clades, the nematodermatids, acoels and xenoturbelids, into the phylum …