The kinetic parameters of enzymes are key to understanding the rate and specificity of most
biological processes. Although specific trends are frequently studied for individual enzymes, …

… Y Savir, T Tlusty, Optimal design of a molecular recognizer: Molecular recognition as a
Bayesian signal detection problem. IEEE J Sel Topics Signal Process 2, 390–399 (2008). …

… The y axis represents expression level. Statistical significance was calculated using one-way
ANOVA followed by the Bonferroni test: *p < 0.05. Data are represented as mean ± SD. …

… The ligand is interacting with a rigid target on which N complementary binding sites are
equally spaced and positioned at y i = y 0 +i·s/(N−1) where s is the length of the target binding …

Natural environments are filled with multiple, often competing, signals. In contrast, biological
systems are often studied in “well-controlled” environments where only a single input is …

Maximizing growth and survival in the face of a complex, time-varying environment is a
common problem for single-celled organisms in the wild. When offered two different sugars as …

… We thank Nati Karin, Keren Yitzhak, Noam Kaplan, and the Savir lab members for fruitful
discussions. This work was supported by the Israel Science Foundation (ISF) grant #1619/20, …

The coronavirus disease 2019 (COVID-19) pandemic has remarkably challenged health
care organizations and societies. A key strategy for confronting the disease implications on …

Gene-regulatory networks achieve complex mappings of inputs to outputs through
mechanisms that are poorly understood. We found that in the galactose-responsive pathway in …

The ribosome is a complex molecular machine that, in order to synthesize proteins, has to
decode mRNAs by pairing their codons with matching tRNAs. Decoding is a major …