Synonymous mutations do not alter the protein produced yet can have a significant effect on
protein levels. The mechanisms by which this effect is achieved are controversial; although …

Synthetic lethality occurs when the inhibition of two genes is lethal while the inhibition of
each single gene is not. It can be harnessed to selectively treat cancer by identifying inactive …

The prioritization of candidate disease-causing genes is a fundamental challenge in the post-genomic
era. Current state of the art methods exploit a protein-protein interaction (PPI) …

10.7554/eLife.03641.001 Utilizing molecular data to derive functional physiological models
tailored for specific cancer cells can facilitate the use of individually tailored therapies. To this …

Many complex human diseases are highly sexually dimorphic, suggesting a potential
contribution of the X chromosome to disease risk. However, the X chromosome has been …

Various studies in unicellular and multicellular organisms have shown that codon bias plays
a significant role in translation efficiency (TE) by co-adaptation to the tRNA pool. Yet, in …

Synonymous mutations are considered to be “silent” as they do not affect protein sequence.
However, different silent codons have different translation efficiency (TE), which raises the …

One of the major challenges in the post-genomic era is elucidating the genetic basis of human
diseases. In recent years, studies have shown that polygenic risk scores (PRS), based on …

The Bene Israel Jewish community from West India is a unique population whose history
before the 18 th century remains largely unknown. Bene Israel members consider themselves …

Cochin Jews form a small and unique community on the Malabar coast in southwest India.
While the arrival time of any putative Jewish ancestors of the community has been speculated …