Single-cell RNA sequencing (scRNA-seq) data are commonly affected by technical artifacts
known as "doublets," which limit cell throughput and lead to spurious biological conclusions. …

The complexity of the human body derives from numerous modular building blocks
assembled hierarchically across multiple length scales. These building blocks, spanning sizes …

The translation of nucleic acid libraries into corresponding synthetic compounds would
enable selection and amplification principles to be applied to man-made molecules. We used …

For many tissues, single resident stem cells grown in vitro under appropriate three-dimensional
conditions can produce outgrowths known as organoids. These tissues recapitulate …

Sample multiplexing facilitates scRNA-seq by reducing costs and identifying artifacts such as
cell doublets. However, universal and scalable sample barcoding strategies have not been …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations
that enable uncontrolled growth and expansion to neighboring and distal tissues. The …

… ZJ Gartner is a Chan Zuckerberg Biohub investigator and is supported by an Era of Hope
Scholar Award (BC123047), the Center for Cellular Construction (NSF DBI-1548297), and the …

Despite their limited chemical functionality, proteins and nucleic acids dominate the solutions
to many complex chemical problems because they can be evolved through iterated cycles …

Multicellular organs comprise differentiated cell types with discrete yet interdependent functions.
The cells' spatial arrangements and interconnectivities, both critical elements of higher-…

Proteins are the primary effectors of cellular function, including cellular metabolism, structural
dynamics, and information processing. However, quantitative characterization of proteins …