Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital
and ubiquitous phenomenon underlying the formation of membraneless organelles in …

Cancer genomic, transcriptomic, and proteomic profiling has generated extensive data that
necessitate the development of tools for its analysis and dissemination. We developed …

Background In response to varied cell stress signals, the p53 tumor-suppressor protein
activates a multitude of genes encoding proteins with functions in cell-cycle control, DNA repair, …

Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the oncogenic
ETS transcription factor ERG occur in approximately 50% of prostate cancers, but how …

Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb
to the disease. Progression to CRPC after androgen ablation therapy is predominantly …

… First, Z score is constructed by mean centering and scale normalization in the conventional
Z statistic, where mean and sd are estimated from the data for each prey. D score is based on …

The interactions of protein kinases and phosphatases with their regulatory subunits and
substrates underpin cellular regulation. We identified a kinase and phosphatase interaction (KPI…

… a particular phase ng configuration Z. Thus, the right-hand side of the equation computes
the “expected frequency” of haplotype g by averaging over all compatible Zs. This equation rep…

… where m is the number of all candidate haplotypes, ni is the number of occurrences of
haplotype i in Z, and the expectation is taken for the ni (which is a function of Z) with v fixed at the …

The mechanisms responsible for the establishment of physical domains in metazoan
chromosomes are poorly understood. Here we find that physical domains in Drosophila …