A key aim of postgenomic biomedical research is to systematically catalogue all molecules
and their interactions within a living cell. There is a clear need to understand how these …

The maintenance of homeostasis in normal tissues reflects a balance between cell proliferation
and cell death. The importance of both positive and negative regulators of cell growth …

This is a comment on" DNA damage can induce apoptosis in proliferating lymphoid cells via
p53-independent mechanisms inhibitable by Bcl-2." Cell. 1994 Oct 21; 79 (2): 329-39. This …

In a cell or microorganism, the processes that generate mass, energy, information transfer
and cell-fate specification are seamlessly integrated through a complex network of cellular …

Proteins are traditionally identified on the basis of their individual actions as catalysts, signalling
molecules, or building blocks in cells and microorganisms. But our post-genomic view is …

Spatially or chemically isolated functional modules composed of several cellular components
and carrying discrete functions are considered fundamental building blocks of cellular …

… Immunoprectpitations were performed as described (Oltvai et al.. 1993), with the exception of
… gel electrophoresis and autoradiography were performed as described (Oltvai et al., 1993). …

BCL-2 was isolated from the t(14;18) chromosomal breakpoint in follicular B-cell lymphoma
1–3 . Bcl-2 has the unique oncogenic role of extending cell survival by inhibiting a variety of …

… Briefly, 0.1 ml of yeast transformant extracts was added to 0.9 ml of Z buffer (60 mM …
Reactions were initiated upon addition of 0.2 ml of ONPG substrate (4 mg/ml) in Z buffer and …

Defining the gene products that play an essential role in an organism's functional repertoire
is vital to understanding the system level organization of living cells. We used a genetic …