DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …

In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu
) – a global alliance of over 500 scientists spread across 200 institutions in 35 countries …

Hypertension can be classified as either Mendelian hypertension or essential hypertension,
on the basis of the mode of inheritance. The Mendelian forms of hypertension develop as a …

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

… We computed a z statistic (22) for the enrichment of P values in the consensus list. Genetic
variation in the consensus list was significantly associated with in vivo rs-fMRI strength …

… The genetic covariance is estimated using the slope from the regression of the product of
z-scores from two GWASs on the LD score. The estimate represents the genetic covariation …

… Feature scaling was performed on continuous and ordinal data by a z-score transformation.
Continuous data were Winsorized (replacing data ±3 sd from the mean with the value at 3 sd …

The growth of white matter during human adolescence shows a striking sexual dimorphism;
the volume of white matter increases with age slightly in girls and steeply in boys. Here, we …

Inter-individual variation in facial shape is one of the most noticeable phenotypes in humans,
and it is clearly under genetic regulation; however, almost nothing is known about the …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …