Cytoplasmic dynein and kinesin-1 are microtubule-based motors with opposite polarity that
transport a wide variety of cargo in eukaryotic cells. Many cellular cargos demonstrate …

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial
Parkinson’s disease 1 and is also linked to its idiopathic form 2 . LRRK2 has been proposed to …

The lissencephaly protein Lis1 has been reported to regulate the mechanical behavior of
cytoplasmic dynein, the primary minus-end-directed microtubule motor. However, the …

Until recently, dynein was the least understood of the cytoskeletal motors. However, a
wealth of new structural, mechanistic, and cell biological data is shedding light on how this …

… Pellman (Harvard) for critically reading the manuscript, as well as all the members of the
Leschziner and Reck-Peterson Labs for advice and helpful discussions. EM data were collected …

The ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone
H2A.Z/H2B dimer for a canonical H2A/H2B dimer at nucleosomes flanking histone-depleted …

Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-pathway
of nucleotide excision repair that preferentially removes DNA lesions from the template …

Cytoplasmic dynein-1 is a molecular motor that drives nearly all minus-end-directed
microtubule-based transport in human cells, performing functions that range from retrograde axonal …

10.7554/eLife.03372.001 Regulation of cytoplasmic dynein's motor activity is essential for
diverse eukaryotic functions, including cell division, intracellular transport, and brain …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial Parkinson’s
disease (PD) and a risk factor for the sporadic form. Increased kinase activity was shown …