Schizophrenia has long been thought to be clinically heterogeneous. A range of studies
suggests that this is due to genetic heterogeneity. Some clinical features, such as negative …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …

Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

Objective: To evaluate previously reported associations of copy number variants (CNVs)
with schizophrenia and to identify additional associations, the authors analyzed CNVs in the …

We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities.
Recent studies have demonstrated a large overlap of genetic risk loci between these disorders …

Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …

A recent genome-wide association study reported association between schizophrenia and
the ZNF804A gene on chromosome 2q32. 1. We attempted to replicate these findings in our …