Therapy resistance and tumour relapse after drug therapy are commonly explained by
Darwinian selection of pre-existing drug-resistant, often stem-like cancer cells resulting from …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …

Ageing is the single greatest cause of disease and death worldwide, and understanding the
associated processes could vastly improve quality of life. Although major categories of …

Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and
its associated diseases. However, the mechanism for this decline is unclear. Here, we show …

Previous studies have shown that mouse dermis is composed of functionally distinct
fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a …

The development of drug resistance, the prime cause of failure in cancer therapy, is
commonly explained by the selection of resistant mutant cancer cells. However, dynamic non-…

SARS-CoV-2 infection is characterized by peak viral load in the upper airway prior to or at
the time of symptom onset, an unusual feature that has enabled widespread transmission of …

Although tremendous effort has been put into cell-type annotation, identification of previously
uncharacterized cell types in heterogeneous single-cell RNA-seq data remains a challenge…