Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Polygenic risk scores (PRSs) have shown promise in predicting susceptibility to common
diseases 1 , 2 – 3 . We estimated their added value in clinical risk prediction of five common …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

Blood concentrations of lipoproteins and lipids are heritable 1 risk factors for cardiovascular
disease 2 , 3 . Using genome-wide association data from three studies (n = 8,816 that …

Background Few studies on long-term exposure to air pollution and mortality have been
reported from Europe. Within the multicentre European Study of Cohorts for Air Pollution Effects (…

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …