This study describes comprehensive polling of transcription start and termination sites and
analysis of previously unidentified full-length complementary DNAs derived from the mouse …

Chronic lymphocytic leukemia (CLL) is a malignancy of B cells of unknown etiology. Deletions
of the chromosomal region 13q14 are commonly associated with CLL, with monoclonal B …

Peripheral T cell lymphomas (PTCLs) are a heterogeneous and poorly understood group of
non-Hodgkin lymphomas 1 , 2 . Here we combined whole-exome sequencing of 12 tumor-…

Inferring, or ‘reverse‐engineering’, gene networks can be defined as the process of
identifying gene interactions from experimental data through computational analysis. Gene …

Glucocorticoid resistance is a major driver of therapeutic failure in T cell acute lymphoblastic
leukemia (T-ALL). Here, we identify the AKT1 kinase as a major negative regulator of the …

Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for ∼5–10% of pediatric
T-ALLs and are associated with poor prognosis. However, the genetic defects that drive …

Activating mutations in NOTCH1 are common in T cell acute lymphoblastic leukemia (T-ALL).
Here we identify glutaminolysis as a critical pathway for leukemia cell growth downstream …

Efforts to identify and annotate cancer driver genetic lesions have been focused primarily on
the analysis of protein-coding genes; however, most genetic abnormalities found in human …

Although multiagent combination chemotherapy is curative in a significant fraction of
childhood acute lymphoblastic leukemia (ALL) patients, 20% of cases relapse and most die …

Angioimmunoblastic T cell lymphoma (AITL) is an aggressive tumor derived from malignant
transformation of T follicular helper (Tfh) cells. AITL is characterized by loss-of-function …