We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26
worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 …

The variant call format (VCF) is a generic format for storing DNA polymorphism data such as
SNPs, insertions, deletions and structural variants, together with rich annotations. VCF is …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

Understanding the genetic structure of human populations is of fundamental interest to
medical, forensic and anthropological sciences. Advances in high-throughput genotyping …

Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

Arabidopsis thaliana is native to Eurasia and is naturalized across the world. Its ability to be
easily propagated and its high phenotypic variability make it an ideal model system for …

COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of 1,051,032 23andMe research participants, we report …

Quantifying patterns of population structure in Africans and African Americans illuminates the
history of human populations and is critical for undertaking medical genomic studies on a …

To further investigate susceptibility loci identified by genome-wide association studies, we
genotyped 5,500 SNPs across 14 associated regions in 8,000 samples from a control group …