By the onset of morphogenesis, Drosophila embryos consist of about 6000 cells that express
distinct gene combinations. Here, we used single-cell sequencing of precisely staged …

Background Recent developments in droplet-based microfluidics allow the transcriptional
profiling of thousands of individual cells in a quantitative, highly parallel and cost-effective way…

Herpesvirus infection initiates a range of perturbations in the host cell, which remain poorly
understood at the level of individual cells. Here, we quantify the transcriptome of single …

Background Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated
with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell responses …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists within …

RNA abundance is tightly regulated in eukaryotic cells by modulating the kinetic rates of
RNA production, processing, and degradation. To date, little is known about time‐dependent …

Acute kidney injury (AKI) is a major health issue, the outcome of which depends primarily on
damage and reparative processes of tubular epithelial cells. Mechanisms underlying AKI …

Background Herpesviruses can infect a wide range of animal species. Herpes simplex virus
1 (HSV-1) is one of the eight herpesviruses that can infect humans and is prevalent …

Organoids derived from stem cells have become an increasingly important tool for studying
human development and modeling disease. However, methods are still needed to control …

Skeletal muscle stem cells, called satellite cells and defined by the transcription factor PAX7,
are responsible for postnatal muscle growth, homeostasis and regeneration. Attempts to …