The first membrane trafficking step in the biosynthetic secretory pathway, the export of proteins
and lipids from the endoplasmic reticulum (ER), is mediated by COPII-coated vesicles. In …

Farming was first introduced to Europe in the mid-seventh millennium bc, and was associated
with migrants from Anatolia who settled in the southeast before spreading throughout …

The COPII complex mediates the selective incorporation of secretory cargo and relevant
machinery into budding vesicles at specialised sites on the endoplasmic reticulum membrane …

Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor.
Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular …

Background While the relation between care involvement of informal caregivers and caregiver
burden is well-known, the additional psychosocial burden related to care involvement …

The sympathetic nervous system inhibits gut motility, secretion, and blood flow in the gut
microvasculature and can modulate gastrointestinal inflammation. Sympathetic neurons signal …

The search for the “gold standard” in the surgical treatment of pterygium has been ongoing
for over two decades. Despite the development of various surgical techniques, recurrence …

Purpose Cisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on
hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer. …

BACKGROUND Combined modality therapy has become the standard of care for
nasopharyngeal carcinoma, yet the combined ototoxic effects of radiation and cisplatin are poorly …

Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance
during development for cell differentiation and tissue morphogenesis as well as in …