Abstract Systems biology has experienced dramatic growth in the number, size, and
complexity of computational models. To reproduce simulation results and reuse models, …

Enzymes catalyse numerous reactions in nature, often causing spectacular accelerations in
the catalysis rate. One aspect of understanding how enzymes achieve these feats is to …

The life histories of two globally endangered hammerhead sharks, Sphyrna lewini and Sphyrna
mokarran, were examined using samples collected from a range of commercial fisheries …

Motivation: The identification of interactions between drugs and target proteins is a key area
in genomic drug discovery. Therefore, there is a strong incentive to develop new methods …

The role of conformational change in substrate binding, catalysis and product release is
reviewed for 11 enzymes, for which crystal structures are available for the apo, substrate- and …

Circulating cell-free DNA (cfDNA) is becoming an important clinical analyte for prenatal
testing, cancer diagnosis and cancer monitoring. The extraction stage is critical in ensuring …

The human proteome is a major source of therapeutic targets. Recent genetic association
analyses of the plasma proteome enable systematic evaluation of the causal consequences of …

Induced pluripotent stem cells (iPSCs), and cells derived from them, have become key tools
for modeling biological processes, particularly in cell types that are difficult to obtain from …

Objective Integration of nutritional, microbial and inflammatory events along the gut-brain
axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate …

The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse
intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to …