This review summarizes recent advances concerning the Nedd8 regulatory pathway in four
areas. One, substantial progress has been made in delineating the role of cullin family …

Given superior analytical features, MS proteomics is well suited for the basic investigation
and clinical diagnosis of human disease. Modern MS enables detailed functional …

This commentary discusses the recent reports in RNA by Yan and colleagues and Westman
and colleagues of the apparent failure of ribavirin to bind to recombinant eIF4E and inhibit 7-…

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated
with activating mutations in NOTCH1 and dysregulation of MYC. Here, we performed 2 …

Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic
form of cell death called pyroptosis in mouse and human monocytes and macrophages 1 , …

The eukaryotic translation initiation factor eIF4E is deregulated in many human cancers, and
its overexpression in cells leads to malignant transformation. Oncogenic properties of eIF4E …

Although the treatment of acute myeloid leukemia (AML) has improved substantially in the
past three decades, more than half of all patients develop disease that is refractory to …

Drugs that target the chief mediator of nuclear export, chromosome region maintenance 1
protein (CRM1) have potential as therapeutics for leukemia, but existing CRM1 inhibitors show …

This study explored the anti‐leukaemic efficacy of novel irreversible inhibitors of the major
nuclear export receptor, chromosome region maintenance 1 ( CRM 1, also termed XPO 1). We …

The BCL11B transcription factor is required for normal T-cell development, and has recently
been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) induced …