Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …

Neurofibromatosis 1 (NF1) is a common neurocutaneous condition with an autosomal
dominant pattern of inheritance. The complications are diverse and disease expression varies, …

The superior surfactant properties of cationic gemini surfactants are applied to the complex
problem of introducing genes into cells. Of almost 250 new compounds tested, of some 20 …

Clean and efficient chemical reactions with complete control of stereochemistry are normal
for enzymes. Nature's supreme catalysts can teach us a great deal about designing artificial …

Background Whole-exome sequencing is a diagnostic approach for the identification of
molecular defects in patients with suspected genetic disorders. Methods We developed technical…

Autism spectrum disorders (ASD) are believed to have genetic and environmental origins,
yet in only a modest fraction of individuals can specific causes be identified 1 , 2 . To identify …

Genomewide association mapping in model organisms such as inbred mouse strains is a
promising approach for the identification of risk factors related to human diseases. However, …

Dissecting the genetic basis of disease risk requires measuring all forms of genetic variation,
including SNPs and copy number variants (CNVs), and is enabled by accurate maps of …

Background: Studies have established that physiologic instability and services mismatching
precede adverse events in hospitalized patients. In response to these considerations, the …

We performed a genome-wide association scan in 1461 patients with bipolar (BP) 1 disorder,
2008 controls drawn from the Systematic Treatment Enhancement Program for Bipolar …