We present Gene-Aware Variant INterpretation (GAVIN), a new method that accurately
classifies variants for clinical diagnostic purposes. Classifications are based on gene-specific …

In the absence of a polyposis phenotype, colorectal cancer (CRC) patients referred for genetic
testing because of early-onset disease and/or a positive family history, typically undergo …

Background Mood disorders can be difficult to treat during pregnancy. There is still lack of
evidence whether pregnancy influences their natural course and whether continuation of …

Chronic kidney disease (CKD) is an increasing health burden (affecting approximately 13.4%
of the population). Currently, no curative treatment options are available and treatment is …

Purpose.: Microcystic macular edema (MME), originally described in British literature as
microcystic macular oedema (MMO), defines microcysts in the inner nuclear layer (INL) of the …

Background: Varying degrees of success have been reported with strategies to increase
milk production when lactation is failing. The objective of this study was to investigate the …

Aims: This study investigated the consequences caregivers of outpatients with bipolar
disorder are confronted with, the distress they experience and their coping styles. Methods: …

INTRODUCTION: Many women with a bipolar disorder are of reproductive age and will need
to continue lithium treatment during pregnancy. The teratogenic and perinatal effects of …

INTRODUCTION: Enoxaparin is the current anticoagulant of choice for neonatal thrombosis.
Present neonatal treatment guidelines of 1.5 mg/kg every 12 hours (q12 h) are extrapolated …

Background: The benefits of breast milk to the newborn infant are well established. The
Canadian Paediatric Society recommends exclusive breastfeeding for the first 6 months of life for …