Mutations in the genes encoding collagen VI (COL6A1, COL6A2, and COL6A3) cause Bethlem
myopathy (BM) and Ullrich congenital muscular dystrophy (UCMD), two conditions which …

Background information Single molecule‐based super‐resolution methods have become
important tools to study nanoscale structures in cell biology. However, the complexity of multi‐…

Membrane cofactor protein (MCP; CD46) is a widely expressed transmembrane complement
regulator. Like factor H it inhibits complement activation by regulating C3b deposition on …

Intense femtosecond x-ray pulses produced at the Linac Coherent Light Source (LCLS) were
used for simultaneous x-ray diffraction (XRD) and x-ray emission spectroscopy (XES) of …

CD4 T cells that recognize peptide antigen in the context of class II MHC can differentiate
into various subsets that are characterized by their helper functions. However, increasing …

Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to
membrane traffic 1 , 2 . Among the seven eukaryotic phosphoinositides the best studied species …

Congenital heart defects (CHDs) have a neonatal incidence of 0.8–1% (refs. 1 , 2 ). Despite
abundant examples of monogenic CHD in humans and mice, CHD has a low absolute …

We asked 78 chronic low back pain patients to report on their usual pain intensity, and on
the lifestyle changes caused by their pain, on a horizontally-oriented visual analogue scale (…

Objective: Childhood abuse, stressful life events, and depression have been repeatedly
reported to correlate with chronic pain, but little is known about the mutual relationships among …

The dioxygen we breathe is formed by light-induced oxidation of water in photosystem II. O
2 formation takes place at a catalytic manganese cluster within milliseconds after the …