User profiles for A. Leemans

Alexander Leemans

Associate Professor, UMC Utrecht, The Netherlands
Verified email at umcutrecht.nl
Cited by 25808

[HTML][HTML] Diffusion tensor imaging and beyond

JD Tournier, S Mori, A Leemans - Magnetic resonance in medicine, 2011 - ncbi.nlm.nih.gov
The diffusion of water molecules inside organic tissues is often anisotropic (1). Namely, if
there are aligned structures in the tissue, the apparent diffusion coefficient (ADC) of water may …

Diffusion MRI fiber tractography of the brain

…, M Descoteaux, S Mori, A Leemans - NMR in …, 2019 - Wiley Online Library
The ability of fiber tractography to delineate non‐invasively the white matter fiber pathways
of the brain raises possibilities for clinical applications and offers enormous potential for …

[HTML][HTML] The challenge of mapping the human connectome based on diffusion tractography

…, M Froeling, AM Heemskerk, A Leemans… - Nature …, 2017 - nature.com
Tractography based on non-invasive diffusion imaging is central to the study of human brain
connectivity. To date, the approach has not been systematically validated in ground truth …

Microstructural maturation of the human brain from childhood to adulthood

C Lebel, L Walker, A Leemans, L Phillips, C Beaulieu - Neuroimage, 2008 - Elsevier
Brain maturation is a complex process that continues well beyond infancy, and adolescence
is thought to be a key period of brain rewiring. To assess structural brain maturation from …

The B‐matrix must be rotated when correcting for subject motion in DTI data

A Leemans, DK Jones - … in Medicine: An Official Journal of the …, 2009 - Wiley Online Library
To estimate diffusion tensor MRI (DTI) measures, such as fractional anisotropy and fiber
orientation, reliably, a large number of diffusion‐encoded images is needed, preferably cardiac …

Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging

B Jeurissen, A Leemans, JD Tournier… - Human brain …, 2013 - Wiley Online Library
It has long been recognized that the diffusion tensor model is inappropriate to characterize
complex fiber architecture, causing tensor‐derived measures such as the primary eigenvector …

Weighted linear least squares estimation of diffusion MRI parameters: strengths, limitations, and pitfalls

J Veraart, J Sijbers, S Sunaert, A Leemans, B Jeurissen - Neuroimage, 2013 - Elsevier
Purpose Linear least squares estimators are widely used in diffusion MRI for the estimation
of diffusion parameters. Although adding proper weights is necessary to increase the …

Methodological considerations on tract-based spatial statistics (TBSS)

M Bach, FB Laun, A Leemans, CMW Tax, GJ Biessels… - Neuroimage, 2014 - Elsevier
Having gained a tremendous amount of popularity since its introduction in 2006, tract-based
spatial statistics (TBSS) can now be considered as the standard approach for voxel-based …

[PDF][PDF] Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning

…, A Smeets, R Peeters, A Leemans… - Journal of Clinical …, 2012 - researchgate.net
Purpose To uncover the neural substrate of cognitive impairment related to adjuvant
chemotherapy, we studied cerebral white matter (WM) integrity before and after chemotherapy by …

Probabilistic fiber tracking using the residual bootstrap with constrained spherical deconvolution

B Jeurissen, A Leemans, DK Jones… - Human brain …, 2011 - Wiley Online Library
Constrained spherical deconvolution (CSD) is a new technique that, based on high‐angular
resolution diffusion imaging (HARDI) MR data, estimates the orientation of multiple …