Genome-wide association study identifies 74 loci associated with educational attainment

…, P Lichtner, D Liewald, LL Cohort Study, A Loukola… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

…, P Kraft, KS Krauter, M Laakso, PA Lind, A Loukola… - Nature …, 2019 - nature.com
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

FinnGen: Unique genetic insights from combining isolated population and national health register data

…, H Laivuori, M Aavikko, MA Kaunisto, A Loukola… - MedRxiv, 2022 - medrxiv.org
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

…, L Franke, R Li-Gao, DC Liewald, M Koini, A Loukola… - Nature …, 2016 - nature.com
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

…, WT Longstreth Jr, OL Lopez, A Loukola… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Population-based molecular detection of hereditary nonpolyposis colorectal cancer

R Salovaara, A Loukola, P Kristo… - Journal of Clinical …, 2000 - ascopubs.org
PURPOSE: Cancer morbidity and mortality can be dramatically reduced by colonoscopic
screening of individuals with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome…

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

…, M Lahti-Pulkkinen, D Lai, L Ligthart, A Loukola… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

[HTML][HTML] FinnGen provides genetic insights from a well-phenotyped isolated population

…, H Laivuori, M Aavikko, MA Kaunisto, A Loukola… - Nature, 2023 - nature.com
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor …

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

…, I Tomlinson, E Avizienyte, S Roth, A Loukola… - Nature, 1998 - nature.com
Studies of hereditary cancer syndromes have contributed greatly to our understanding of
molecular events involved in tumorigenesis. Here we investigate the molecular background of …

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

…, J Laitinen, R Lemaitre, A Loukola… - Proceedings of the …, 2016 - National Acad Sciences
Excessive alcohol consumption is a major public health problem worldwide. Although drinking
habits are known to be inherited, few genes have been identified that are robustly linked …