The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role
of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the …

Programmed cell death plays an important role in the neuronal degeneration after cerebral
ischemia, but the underlying mechanisms are not fully understood. Here we examined, in …

Invasion of surrounding brain tissue by isolated tumor cells represents one of the main
obstacles to a curative therapy of glioblastoma multiforme. Here we unravel a mechanism …

The function of somatic stem cells declines with age. Understanding the molecular underpinnings
of this decline is key to counteract age-related disease. Here, we report a dramatic …

Memory impairment has been associated with age-related decline in adult hippocampal
neurogenesis. Although Notch, bone morphogenetic protein, and Wnt signaling pathways are …

Background—The death of cardiac cells during ischemia and reperfusion is partially mediated
by apoptosis, as seen, eg, in autopsy material of patients after acute myocardial infarction. …

Heterogeneous pools of adult neural stem cells (NSCs) contribute to brain maintenance
and regeneration after injury. The balance of NSC activation and quiescence, as well as the …

Despite extensive effort on studying inflammatory processes in the CNS of Parkinson’s disease
(PD) patients, implications of peripheral monocytes are still poorly understood. Here, we …

Transcription factor c-Jun is proposed to control neuronal cell death and survival, but its
activation by N-terminal phosphorylation and the underlying activity of the c-Jun N-terminal …

Objective To examine whether apoptosis contributes to the pathogenesis of skin lesions in
patients with cutaneous lupus erythematosus (CLE) after ultraviolet (UV) irradiation. Methods …