p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis.
Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic …

Melanoma is the deadliest form of skin cancer and one of the most difficult cancers to treat.
Overall, melanomas have more mutations than any other cancer type. Oncogenic mutations …

An industry-wide mortality study on the association between lung cancer and occupational
exposure to cobalt and tungsten carbide was carried out in the French hard-metal industry. …

Transitional B cells have been recently identified in human peripheral blood. However, their
precise role in human B cell differentiation has not been established. Therefore, besides …

BACKGROUND Spermatozoa with large vacuoles (SLV) may have a negative impact on
embryo development. The origin of these vacuoles is unknown. We evaluated acrosome and …

BACKGROUND Approximately 10 years after the first publication introducing the motile
sperm organelle morphology examination (MSOME), many questions remained about sperm …

Testicular cancer is the most common cancer in young men. Several studies have reported
an alteration in semen quality in nonseminoma tumors, but this result has not been confirmed …

STUDY QUESTION Is fertility preservation feasible after the onset of puberty in adolescents
with Klinefelter syndrome (KS)? SUMMARY ANSWER Fertility preservation counseling …

Background: The direct comparison of CA19. 9, circulating tumour cells (CTCs) and circulating
tumour DNA (ctDNA) using endoscopic ultrasound-guided fine needle aspiration (EUS-…

Acquired estrogen receptor gene (ESR1) mutations have been recently reported as a marker
of resistance to aromatase inhibitors in hormone receptor positive metastatic breast cancer. …