User profiles for A. Sexton-Oates
 | Alexandra Sexton-OatesInternational Agency for Research on Cancer Verified email at iarc.who.int Cited by 863 |
[HTML][HTML] Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing data, …
challenging clinical management. Through a large series of whole-genome sequencing data, …
[HTML][HTML] Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 …
…, N Altman, E Lavi, R Saffery, A Sexton-Oates… - Acta …, 2017 - Springer
Epileptogenic tumors affecting children and young adults are a morphologically diverse
collection of neuroepithelial neoplasms that, as a group, exhibit varying levels of glial and/or …
collection of neuroepithelial neoplasms that, as a group, exhibit varying levels of glial and/or …
[HTML][HTML] Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood
…, DP Burgner, A Czajko, B Kim, A Sexton-Oates… - Nature …, 2019 - nature.com
More than 7 million individuals have been conceived by Assisted Reproductive Technologies
(ART) and there is clear evidence that ART is associated with a range of adverse early life …
(ART) and there is clear evidence that ART is associated with a range of adverse early life …
Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy
D Martino, JE Joo, A Sexton-Oates, T Dang, K Allen… - Epigenetics, 2014 - Taylor & Francis
Food allergy is mediated by a combination of genetic and environmental risk factors,
potentially mediated by epigenetic mechanisms. CD4+ T-cells are key drivers of the allergic …
potentially mediated by epigenetic mechanisms. CD4+ T-cells are key drivers of the allergic …
Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants
Background The diagnosis of food allergy (FA) can be challenging because approximately
half of food-sensitized patients are asymptomatic. Current diagnostic tests are excellent …
half of food-sensitized patients are asymptomatic. Current diagnostic tests are excellent …
[PDF][PDF] Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites
…, WM Hackeng, K Samsom, C Voegele, A Sexton-Oates… - Cancer cell, 2023 - cell.com
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors (NETs)
and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns
Replication repair deficiency (RRD) leading to hypermutation is an important driving
mechanism of high-grade glioma (HGG) occurring predominantly in the context of germline …
mechanism of high-grade glioma (HGG) occurring predominantly in the context of germline …
Epigenetic deregulation in pediatric acute lymphoblastic leukemia
Similar to most cancers, genome-wide DNA methylation profiles are commonly altered in
pediatric acute lymphoblastic leukemia (ALL); however, recent observations highlight that a …
pediatric acute lymphoblastic leukemia (ALL); however, recent observations highlight that a …
[HTML][HTML] The potential for epigenetic analysis of paediatric CNS tumours to improve diagnosis, treatment and prognosis
A Sexton-Oates, D MacGregor, A Dodgshun… - Annals of Oncology, 2015 - Elsevier
Tumours of central nervous system (CNS) origin are the second most prevalent group of
cancers in children, yet account for the majority of childhood cancer-related deaths. Such …
cancers in children, yet account for the majority of childhood cancer-related deaths. Such …
[HTML][HTML] Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related
death in children aged 0–14 years. They differ from their adult counterparts, showing …
death in children aged 0–14 years. They differ from their adult counterparts, showing …