We describe two structures of the intact bacterial ribosome from Escherichia coli determined
to a resolution of 3.5 angstroms by x-ray crystallography. These structures provide a …

Bacterial communities are important not only in the cycling of organic compounds but also in
maintaining ecosystems. Specific bacterial groups can be affected as a result of changes in …

During environmental stress, organisms limit protein synthesis by storing inactive ribosomes
that are rapidly reactivated when conditions improve. Here we present structural and …

The prokaryotic ribosome is an important target of antibiotic action. We determined the X-ray
structure of the aminoglycoside kasugamycin (Ksg) in complex with the Escherichia coli 70S …

Connexins (Cxs) are integral membrane proteins that form high-conductance plasma membrane
channels, allowing communication from cell to cell (via gap junctions) and from cells to …

Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can
differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear …

Three ribosomal RNA mutations conferring resistance to the antibiotic kasugamycin were
isolated using a strain of Escherichia coli in which all of the rRNA is transcribed from a plasmid-…

Mutations of mitochondrial DNA are linked to many human diseases. Despite the identification
of a large number of variants in the mitochondrially encoded rRNA (mt-rRNA) genes, the …

Protein biosynthesis on the ribosome requires accurate reading of the genetic code in mRNA.
Two conformational rearrangements in the small ribosomal subunit, a closing of the head …

It is well known that agricultural practices change the physical and chemical characteristics
of soil. As a result, microbial populations can also be affected. The aim of this study was to …