User profiles for B. B. Shih

Barbara Shih

Lancaster University
Verified email at lancaster.ac.uk
Cited by 4077

Immune cell gene signatures for profiling the microenvironment of solid tumors

AJ Nirmal, T Regan, BB Shih, DA Hume, AH Sims… - Cancer immunology …, 2018 - AACR
… Regan, BB Shih, and TC Freeman are funded by MRC consortium grants (MR/M003833/1
and MR/L014815/1); TC Freeman is funded by an Institute Strategic Grant from the …

[HTML][HTML] Fractional sunburn threshold UVR doses generate equivalent vitamin D and DNA damage in skin types I–VI but with epidermal DNA damage gradient …

BB Shih, MD Farrar, MS Cooke, J Osman… - Journal of Investigative …, 2018 - Elsevier
Public health guidance recommends limiting sun exposure to sub-sunburn levels, but it is
unknown whether these can gain vitamin D (for musculoskeletal health) while avoiding …

[HTML][HTML] Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging

ES Chambers, M Vukmanovic-Stejic, BB Shih… - Nature Aging, 2021 - nature.com
We have previously shown that healthy older adults exhibit reduced cutaneous immune
responses during a varicella zoster virus (VZV) antigen challenge that correlated with a …

[PDF][PDF] Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma

…, SA Quinn, WHW Lin, AP Laurent, BB Shih… - Cell reports, 2022 - cell.com
Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) comprises heterogeneous
lymphoid malignancies characterized by pleomorphic lymphocytes and variable …

[HTML][HTML] Computational analysis of SARS-CoV-2 and SARS-like coronavirus diversity in human, bat and pangolin populations

NJ Dimonaco, M Salavati, BB Shih - Viruses, 2020 - mdpi.com
In 2019, a novel coronavirus, SARS-CoV-2/nCoV-19, emerged in Wuhan, China, and has
been responsible for the current COVID-19 pandemic. The evolutionary origins of the virus …

[HTML][HTML] Graphia: A platform for the graph-based visualisation and analysis of high dimensional data

…, A Patir, J Harling-Lee, T Regan, BB Shih… - PLoS computational …, 2022 - journals.plos.org
Graphia is an open-source platform created for the graph-based analysis of the huge amounts
of quantitative and qualitative data currently being generated from the study of genomes, …

Graphia: A platform for the graph-based visualisation and analysis of complex data

…, S Horsewell, A Patir, J Harling-Lee, T Regan, BB Shih… - BioRxiv, 2020 - biorxiv.org
Quantitative and qualitative data derived from the analysis of genomes, genes, proteins or
metabolites from tissue or cells are currently generated in huge volumes during biomedical …

Vitamin D3 replacement enhances antigen-specific immunity in older adults

…, CT Turner, BB Shih… - Immunotherapy …, 2021 - academic.oup.com
Introduction Ageing is associated with increased number of infections, decreased vaccine
efficacy and increased systemic inflammation termed inflammageing. These changes are …

[HTML][HTML] Jak-STAT inhibition mediates romidepsin and mechlorethamine synergism in cutaneous T-cell lymphoma

…, A Mackey, AJ Cooke, BB Shih… - Journal of Investigative …, 2021 - Elsevier
Sézary syndrome is an aggressive and disseminated form of cutaneous T-cell lymphoma
associated with dismal prognosis in which the histone deacetylase inhibitor romidepsin has …

[HTML][HTML] Aging-related impairments to M cells in Peyer's patches coincide with disturbances to Paneth cells

DS Donaldson, BB Shih, NA Mabbott - Frontiers in Immunology, 2021 - frontiersin.org
The decline in mucosal immunity during aging increases susceptibility, morbidity and
mortality to infections acquired via the gastrointestinal and respiratory tracts in the elderly. We …