… Binding of a NURC or HAT complex (depicted as single ovals) to histone tails may be
mediated by the bromodomain (BD). Although many of the complexes identified to date are …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

In the last few years, the discovery of lysine and arginine methylation in histones and other
proteins and the enzymes that carry out these posttranslational modifications has added a …

The organization of chromatin into higher-order structures influences chromosome function
and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated …

The assembly of higher order chromatin structures has been linked to the covalent modifications
of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 Lys 9 ) is …

Acetylation of core histone tails plays a fundamental role in transcription regulation. In
addition to acetylation, other posttranslational modifications, such as phosphorylation and …

The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription
initiation. Biochemical, genetic, and gene-expression analyses show that Rpd3 exists in two …

The identification of nuclease-hypersensitive sites in an active globin gene 1 and in the 5′
regions of fruit fly heat shock genes 2 first suggested that chromatin changes accompany …

Histone methylation is known to be associated with both transcriptionally active and repressive
chromatin states. Recent studies have identified SET domain–containing proteins such …

Recent studies of histone methylation have yielded fundamental new insights pertaining to
the role of this modification in gene activation as well as in gene silencing. While a number of …