Understanding the spatial organization of gene expression with single-nucleotide resolution
requires localizing the sequences of expressed RNA transcripts within a cell in situ. Here, …

RNA-sequencing (RNA-seq) measures the quantitative change in gene expression over the
whole transcriptome, but it lacks spatial context. In contrast, in situ hybridization provides the …

… Turczyk,1 excised introns in cellular senescence. Circular double William F. Donahue,1
Avital Bar-Shalom,2 stranded DNA molecules comprised of tandem repeats and Kevin A. …

Here, we present a generalized method of guide RNA “tuning” that enables Cas9 to discriminate
between two target sites that differ by a single-nucleotide polymorphism. We employ …

We seek to create useful biological diversity by exploiting the modular nature of genetic
information. In this report we describe experiments that focus on the modular nature of plasmid …

Few point mutations have been described that specifically inhibit the second step of group II
intron splicing. Furthermore, the effects of such mutations are typically not apparent unless …

Fluorescent spatial sequencing brings next-generation sequencing into a new realm capable
of identifying nucleic acids in the cell’s natural environment. For the first time, scientists are …

… In memory of my late father, Michael Jan Turczyk, who provided unlimited support and
direction in my life. May I one day come close to being the thoughtful and understanding man you …

We give a systematic way to compute higher orders in the 1/mb expansion in inclusive semi-leptonic
decays at tree-level. We reproduce the known 1/mb 3 terms and compute the 1/mb …

Many models for physics beyond the Standard Model predict lepton-flavour violating decays
of charged leptons at a level which may become observable very soon. In the present paper …