… BRAF encodes a protein called B-Raf that constitutes a crucial step in the RAS-mitogen
activated protein kinase (RAS-MAPK) signal pathway. BRAF mutations are present in 7–10% of …

… To analyze the influence of normal T cells present in the CLL samples, we mixed different
concentrations of mononuclear cells from healthy blood donors with REC cells, a B-cell line …

… B-cell CLL is characterized by the accumulation of long-lived, functionally inactive, mature
… , neoplastic B-lymphocytes arrested in the G0 phase of the cell cycle. The clonal excess of B …

Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and
clonal evolution. The molecular profile of CRC is routinely assessed in surgical or bioptic …

Since the discovery of the JAK 2 V617F mutation in the majority of the myeloproliferative
neoplasms ( MPN ) of polycythemia vera, essential thrombocythemia and primary myelofibrosis …

Background Cancers result from the accumulation of somatic mutations, and their properties
are thought to reflect the sum of these mutations. However, little is known about the effect of …

… (b) Sensitivity to cetuximab is correlated with the effective inhibition of EGFR downstream
effectors (AKT and ERK). Cell lysates from DiFi cells and DCRs were collected after 2 h of …

Background RAS assessment is mandatory for therapy decision in metastatic colorectal
cancer (mCRC) patients. This determination is based on tumor tissue, however, genotyping of …

Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin production
is unknown. Here we identified neutrophils around the marginal zone (MZ) of the spleen, …

… The adjusted cumulative incidence of hematologic transformation according to resistance
to HU is shown in Figure 3B. Intolerance to HU, as defined by the ELN, did not show any …