Background Multiple studies have compared the performance of artificial intelligence (AI)–based
models for automated skin cancer classification to human experts, thus setting the …

Malignant melanoma contributes the majority of skin cancer related deaths and shows an
increasing incidence in the past years. Despite all efforts of early diagnosis, metastatic …

The development of genetic tools allowed for the validation of the pro-aging and pro-disease
functions of senescent cells in vivo. These discoveries prompted the development of …

… (B) Patients were stratified into response groups based on RECIST criteria (21) (CR, complete
response; PR, partial response; SD, stable disease; PD, progressive disease; MR, mixed …

As tumors grow, they acquire mutations, some of which create neoantigens that influence
the response of patients to immune checkpoint inhibitors. We explored the impact of …

Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-cell
communication in which microRNAs (miRNAs) produced and released from one cell are …

Verification of candidate biomarkers relies upon specific, quantitative assays optimized for
selective detection of target proteins, and is increasingly viewed as a critical step in the …

… (B) Method to discover malignant cell programs associated with immune cell infiltration or
exclusion. (C and D) Distinct profiles of malignant and non-malignant cells. t-stochastic …

… (for example, B cell markers enriched in ipilimumab-experienced responders) in ICB response,
consistent with data from a recent trial demonstrating higher B cell infiltrate in responders …

The senescence-associated secretory phenotype (SASP) has recently emerged as a driver
of and promising therapeutic target for multiple age-related conditions, ranging from …